Atypical Spitz nevus. Spitzoid melanoma: asymmetric, irregular lateral borders, uneven base, pagetoid scatter of melanocytes, uneven nests of melanocytes, lack of maturation, spindle cells not perpendicular to surface, epidermal spread, ulcerated surface, most cells appear malignant ( Clin Dermatol 2009;27:545 ) Back to top Desmoplastic Spitz naevus (DSN), first described by Reed et al. in 1975 (2). Histopathologically, desmoplastic Spitz naevus is characterized by epithelioid and/or fusiform-shaped cells surrounded by a fibrous stroma consisting of thick bundles of collagen Desmoplastic intradermal spitz nevi arising within red tattoo ink. Saunders BD, Nguyen M, Joo JS, Konia TH, Tartar DM(1). Author information: (1)Department of Dermatology, University of California Davis, School of Medicine, Sacramento, California. email@example.com. Tattoos present a diagnostic challenge for dermatologists
Most desmoplastic Spitz nevi are intradermal or predominantly intradermal. Pigmented spindle cell nevus (Reed nevus) is regarded by most authorities as a clinically and histologically distinct.. A subset of Spitz nevi, in particular desmoplastic Spitz nevus, is associated with copy gains for 11p, which includes the HRAS locus and is usually associated with overexpression of HRAS Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Harvell JD(1), Bastian BC, LeBoit PE. Author information: (1)Department of Pathology, Stanford University Medical Center, Stanford, California, USA Desmoplastic melanoma is an insidious malignant melanoma subtype that commonly occurs on sun‐damaged skin of the head and neck area in elderly patients. The diagnostic conundrum occurs with confusion of desmoplastic melanoma with scars, hyalinizing blue nevi, desmoplastic Spitz nevi and diffuse neurofibromas
Definition: Spitz nevus is usually a pink papule on the extremities or face of young patients. It has little pigmentation, spindle and epithelioid cells, is usually compound, and may have eosinophilic globules known as Kamino bodies.. Images. Spitz nevus: Melanocytes with ample cytoplasm.Note the collagenous stroma which adds desmoplastic part of the name Klaus J. Busam, in Pathology of Melanocytic Tumors, 2019 Desmoplastic Melanoma Versus Sclerosing Spitz Nevus Sclerosing Spitz nevi are characterized by the presence of amelanotic spindle and epithelioid melanocytes with enlarged nuclei and often abundant pink cytoplasm. The nuclei may be round to oval or elongated
Five of the 10 Spitz nevi with BRAF mutations were altered by more than usual cytologic atypia and/or architectural atypia overlapping with dysplastic nevi, or irritation/ inflammation; one desmoplastic Spitz nevus had a BRAF mutation Nojavan H, Cribier B, Mehregan DR. [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma]. Ann Dermatol Venereol. 2009 Oct. 136(10):689-95. . Ko CJ, McNiff JM, Glusac EJ. Melanocytic nevi with features of Spitz nevi and Clark's/dysplastic nevi (Spark's nevi). J Cutan Pathol. 2009 Oct. 36(10):1063-8
In medicine, desmoplasia is the growth of fibrous or connective tissue. It is also called desmoplastic reaction to emphasize that it is secondary to an insult. Desmoplasia may occur around a neoplasm, causing dense fibrosis around the tumor, or scar tissue (adhesions) within the abdomen after abdominal surgery (Redirected from Desmoplastic Spitz naevus) A Spitz nevus is a benign skin lesion. A type of melanocytic nevus, it affects the epidermis and dermis. It is also known as an epithelioid and spindle-cell nevus, and misleadingly as a benign juvenile melanoma, and Spitz's juvenile melanoma) Dermal scar. Diagnosis in short. Dermal scar. H&E stain. LM. dense collagen - fibers run parallel to the DE junction, loss of dermal papilla, loss of adnexal structures, thin-wall blood vessels. LM DDx. malignant melanoma desmoplastic-neurotropic type, dermatofibroma, desmoplastic Spitz nevus, sclerosing blue nevus. Stains
The spitz nevus: review and update. Lyon VB. Clin Plast Surg. 2010 Jan;37(1):21-33. (REVIEW) PMID 19914455 : Spitz nevus versus spitzoid melanoma: diagnostic difficulties, conceptual controversies. Mooi WJ, Krausz T. Adv Anat Pathol. 2006 Jul;13(4):147-56. PMID 16858148 : Spitz nevus and its histologic simulators. Mooi WJ. Adv Anat Pathol. 2002. Fifteen sclerosing melanocytic nevi, including desmoplastic Spitz nevi, conventional nevi with prominent stromal sclerosis and sclerotic blue nevi, as well as 15 examples of desmoplastic melanoma, were examined. None of the sclerosing melanocytic nevi showed a level of chromosomal aberrations that met FISH criteria for melanoma COMBINED MELANOCYTIC NEVUS Microscopy: • Common combinations is a compound melanocytic nevus and a blue nevus • The epithelioid blue nevus is often part of a combined nevus that may include Spitz nevus, desmoplastic nevus, or congenital nevus • The melanocytes in blue nevi of all types express S100 protein, melan-A (MART-1), and HMB-45 Intradermal Spitz nevus is a distinctive type of Spitz nevus that sometimes can be difficult to define given the unusual features that these lesions can show; thus, strict application of well-defined histological criteria and awareness of their morphological spectrum will facilitate definitive diagnosis Desmoplastic Spitz nevus Differential diagnosis : • other forms of sclerosing nevus, ie : • desmoplastic type A nevus • desmoplastic combined nevus • sclerosing fibrohistiocytic lesion • desmoplastic melanoma Spindle cell nevus (Reed et al., 1975) Clinical features : • black or dark dome shaped lesion • 2-6 mm in diamete
Desmoplastic Spitz Nevi Desmoplastic Spitz Nevi Hughes, A.; Mehregan, D. R. 2005-01-01 00:00:00 We have reviewed sixteen patients with the diagnosis of desmoplastic Spitz nevus. The age of our patients ranged between seven years and fifty‐four years. We noted a predominance of twelve female patients and four male patients Five cases of a distinctive variant of desmoplastic Spitz nevus are reported. To the best of our knowledge, this tumor has never been described previously. Clinically, it presents itself as a solitary papule on the extremities of young adults. Microscopically, it shows predominance of solitary melanocytes with epithelioid appearance over cell. Although Spitz nevi are clinically heterogeneous, one presenting as a keloidal nodule has not been previously published. We present a case of an angiomatoid and desmoplastic Spitz nevus clinically akin to a keloid on an African‐American teenager and describe its unique histopathologic features The nevus spilus and congenital-pattern nevus contained a mutation in FGFR4 (R401P) that was not found in the desmoplastic Spitz nevi. No abnormalities of NRAS were found in any of the lesions. Mutations in FBXW7 and PDGFRB were shared among all four specimens Objective To achieve a clinicopathologic classification of Spitz nevi by comparing their clinical, dermoscopic, and histopathologic features.Design Eighty-three cases were independently reviewed by 3 histopathologists and preliminarily classified into classic or desmoplastic Spitz nevus..
Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms. Modern Pathology, 34(2), 348-357. However, there was a significant range in microscopic appearances, including two cases with morphologic features of a desmoplastic Spitz nevus. Different binding partners to ROS1 were identified with PWWP2A and TPM3 being the most. . A Spitz naevus is a benign skin tumour. However, it may resemble a melanoma clinically and microscopically, so Spitz naevi are often excised as a precaution. Spitz naevi. Classic Spitz naevus o learn more about the spectrum of microscopic and cytogenetic changes that can be seen in Spitz lesions in association with 11p gains, we reviewed the clinical and pathologic features of 40 cases. Patient ages ranged from 3 to 75 years. The most common anatomic site was the head and neck region, followed by the upper extremities. Prominent desmoplasia was present in 10 cases. Seven tumors.
Desmoplastic melanocytic nevi can be difficult to distinguish from desmoplastic melanoma. The presence of lymphocytic aggregates in association with a sclerosing melanocytic proliferation is commonly regarded as a feature in support of a diagnosis of desmoplastic melanoma. However, the finding is not specific for melanoma Clinical findings in ROS1 fusion Spitz neoplasms. The final diagnosis from the time of clinical care in the set of 17 ROS1 Spitz neoplasms was Spitz nevus in ten cases and Spitz tumor in seven.
One Spitz nevus with a BRAF mutation was an intradermal desmoplastic Spitz nevus. Seven of the 10 Spitz nevi demonstrated some degree of epidermal hyperplasia and four cases had Kamino bodies For the Distinction of a Desmoplastic Spitz Nevus from Desmoplastic Melanoma. In contrast to desmoplastic melanomas, most desmoplastic melanocytic nevi express Melan-A/MART1 and often also p16. Thus, when confronted with a sclerosing melanocytic neoplasm, positive labeling for these markers favors a nevus, but correlation with the clinical and. Of the neoplastic cases identified, it is unclear whether the tattoo ink was directly causative, or if the cases were merely coincidence, as the number of cutaneous malignancies has also been on the rise. We present a novel case of two desmoplastic intradermal Spitz nevi arisinq within red tattoo ink
GEORGE P. WYSOCKI DDS, PHD, in Contemporary Oral and Maxillofacial Pathology (Second Edition), 2004. Spitz Nevus CLINICAL FEATURES. The Spitz nevus is also known as spindle and epithelioid cell nevus and formerly called a benign juvenile melanoma. It is an uncommon type of melanocytic nevus that typically presents as a solitary small pink. Desmoplastic (sclerotic) nevus, a benign melanocytic neoplasm characterized by predominantly spindle-shaped nevus cells within a fibrotic stroma, can be confused with fibrous lesions and other melanocytic proliferations, including desmoplastic melanoma. We compared the histologic and immunohistochemical features of 16 desmoplastic nevi, nine desmoplastic melanomas, four hypopigmented blue nevi.
Multiple studies have also incorporated specialized types of melanocytic lesions, such as Spitz lesions, 58-61,64,66,68 desmoplastic melanomas, 58,67,71 blue nevus-related lesions, 69,71 and mucosal melanocytic lesions 41,49,62,63 ; 2 studies 43,70 focused on nodal metastases, and a recent study (S. S. Koh, unpublished data, 2018) compared. Terminology. Desmoplasia originates from the Ancient Greek δεσμός desmos, knot, bond and πλάσις plasis, formation.It is usually used in the description of desmoplastic small round cell tumors.. Neoplasia is the medical term used for both benign and malignant tumors, or any abnormal, excessive, uncoordinated, and autonomous cellular or tissue growth Mooi W.J., Krausz T. (1992) Spitz naevus, desmoplastic Spitz naevus and pigmented spindle cell naevus. In: Biopsy Pathology of Melanocytic Disorders. Biopsy Pathology Series Spitzoid melanocytic lesions may be broadly categorized into Spitz nevi, ASTs, and spitzoid melanomas. 2-4 Classically, the Spitz nevus presents as a dome-shaped, pink to reddish-brown papule or nodule, usually less than 6 mm in diameter. 4 Spitz nevi commonly arise in childhood but may occur at any age. Lott et al 3 recently studied the clinical features of 484 Spitz nevi in comparison with.
Angiomatoid Spitz nevus is a recently described subtype of desmoplastic Spitz nevus. Six cases have been described in the literature thus far. Here, we describe six additional cases of angiomatoid Spitz nevus and provide a review of the literature on this entity Melanocytic lesions. A melanocytic lesion ( blue nevus ). H&E stain. (WC/Nephron) Melanocytic lesions are commonly encountered in dermatopathology and an area which causes some difficulty, i.e. it is hard to decide in some cases whether a lesion is benign (e.g. Spitz nevus) or malignant ( malignant melanoma )
Spitz nevus is a variant of melanocytic nevus which is histopathologically defined as large spindle and/or epithelioid cells. Angiomatoid Spitz nevus is a rare histologic variant of desmoplastic Spitz nevus characterized by prominent vasculature. We present a case of angiomatoid Spitz nevus, celluar type, that has not been reported before Harris GR, Shea CR, Horenstein MG, Reed JA, Burchette Jr JL, Prieto VG. Desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma. Am J Surg Pathol. 1999;23(7):786-94. PubMed CrossRef Google Schola
Dermal scar. Diagnosis in short. Dermal scar. H&E stain. LM. dense collagen - fibers run parallel to the DE junction, loss of dermal papilla, loss of adnexal structures, thin-wall blood vessels. LM DDx. malignant melanoma desmoplastic-neurotropic type, dermatofibroma, desmoplastic Spitz nevus, sclerosing blue nevus. Stains A rare variant is the desmoplastic Spitz nevus in which the proliferating large epithelioid and/or fusiform melanocytes are embedded in a desmoplastic stroma with thick eosinophilic collagen bundles Spitz nevus with rosette‐like structures: a new histologic variant Spitz nevus with rosette‐like structures: a new histologic variant Sara, Kantrow; George C., Kalemeris; Prieto, Victor 2008-05-01 00:00:00 To the Editor , Originally described in 1948 as melanoma of childhood, Spitz nevi are composed of epithelioid and spindled melanocytes, although either morphologic component may predominate To the Editor: A prominent vascular component has been rarely described in melanocytic lesions. Diaz-Cascajo et al 1 were the first to report a particular variant of desmoplastic Spitz nevus with a striking fibrous stroma and many densely arranged small blood vessels. Due to its similarity to a vascular tumor, they proposed the term of angiomatoid nevus for this condition , Ji Soo Urn, Yun Scon Choc, Jung Ho Kim , Hyun Sun Yoon , Soyun Cho , Hyun Sun Park Pathology
A rare variant is the desmoplastic Spitz nevus in which the proliferating large epithelioid and/or fusiform melanocytes are embedded in a desmoplastic stroma with thick eosinophilic collagen bundles.  Professor of Pathology, University of Texas McGovern Medical School at Houston. Disclosure: Book royalties from Elsevier publishers Abstract The desmoplastic melanocytic nevus is an uncommon variant that easily may be confused with a fibrohistiocytic neoplasm or a desmoplastic melanoma. It is believed that the following report describes the first known example of a desmoplastic melanocytic nevus arising in the oral mucosa Pedrazini MC, Montalli VAM, Souza EM. The Fast Clinical Evolution of a Spitz Nevus: Three-Year Follow-Up of a Child. Rev Paul Pediatr. 2017 Oct-Dec. 35 (4):476-479.. Kim D, Khan AU, Compres EV. The desmoplastic melanocytic nevus is an uncommon variant that easily may be confused with a fibrohistiocytic neoplasm or a desmoplastic melanoma. It is believed that the following report describes the first known example of a desmoplastic melanocytic nevus arising in the oral mucosa. The histopathologic and immunohistochemical features that allow separation from other microscopically similar. Spitzoid melanocytic lesion, favor spitz nevus (spindle and epitheloid cell nevus) compound type, margins involved. Further surgical excision advised. Post excision-scar, no residual nevus seen. I was DISTURBED by the lack on information in this first pathology report so I switched dermatologists and sent the specimen to a second lab
The halo nevus is defined as a pigmented lesion with usually benign clinical characteristics surrounded by a zone of depigmentation that is symmetrically disposed .This rim of depigmentation gives rise to the name halo. Histologically there is a compound nevus usually associated to a very striking, band-like, infiltrative lymphocyte response that is present among the dermal component of the. The Fast Clinical Evolution of a Spitz Nevus: Three-Year Follow-Up of a Child. Rev Paul Pediatr. 2017 Oct-Dec. 35 (4):476-479. [Medline]. Kim D, Khan AU, Compres EV, Zhang B, Sunshine JC, Quan VL. Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma. Am J Surg Pathol . 2005 Sep. 29(9):1145-51. [Medline] Spitz nevus: a distinct variant of desmoplastic spitz nevus with prominent vasculature. Am J Dermato-pathol 2000;22:135-139. 2.McKee PH, Calonje E, Granter SR. Spitz nevus, atypical spitz nevus and spitzoid melanoma. In: McKee PH, editor. Pathology of the skin. 3rd ed. London: Elsevier Mosby, 2005:1268-1275. 3. Paniago-Pereira C, Maize JC.
Hilliard NJ, Krahl D, Sellheyer K. p16 expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma. J Cutan Pathol. (2009) 36:753-9. doi: 10.1111/j.1600-0560.2008.01154. Desmoplastic Spitz nevus: A histopathological review and comparison with desmoplastic melanoma. Annales de Dermatologie et de Vénéréologie 136(10):689-95, 2009. • Rosner, K., D. Moussai, D. R. Mehregan, et al. WT1 marker is not sufficient for distinguishing between melanoma and melanocytic nevi Desmoplastic Spitz nevus. i67 x 200. Occasional nuclei posi-tive for ki67 (ki67 index less than 1%). Basal and parabasal epider-mal cells positive for ki67 (internal control). Figure 1I. Figure 1L. Desmoplastic Spitz nevus. HMB45 x 100. HMB45 positive in superficial part of the tumor and negative in deepest part; nontumor active epidermal. . We conclude that although desmoplastic Spitz nevus occurs much more commonly in adolescents, desmoplastic malignant melanoma can occur in this age group and even in non-sun-exposed skin Department of Pathology, MM Medical College, Mullana-Ambala, Haryana, India. separate entity from Spitz nevus . Desmoplastic Spitz nevus: It is characterized by the presence of extensive stromal desmoplasia in Spitz nevi of predominantly dermal location, which encircles the individual cells and simulates an invasive.
Classical Spitz nevi are made up of large spindle and ⁄or epithelioid cells that are mainly arranged in nests. Pigmentation is usually sparse or may even be absent. The dermal component often has a desmoplasia encircling single melanocytes ('desmoplastic Spitz nevus '). It should be noted that melanoma might rarely exhibit a type of. Visit: Pathology of Spitz Naevus Abstract: Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma. Ann Dermatol Venereol. 2009 Oct;136(10):689-95. INTRODUCTION: Desmoplastic Spitz nevus is a rare variant of spitzoid tumours characterized by dermal proliferation of large epitheliod and/or fusiform. papilliferum, tubular adenoma and a Spitz nevus (24). Moreover, the desmoplastic Spitz nevus phe-notype is not restricted to HRAS mutated lesions since rare Spitz nevi harboring ROS1, ALK or even a BRAF fusion exhibiting a desmoplastic Spitz ne-vus morphology have been described (2, 32). Even though the vast majority of Spitz prolif-erations. . Spitzoid melanoma is a type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin. Spitzoid melanoma looks very much like an uncommon but benign skin mole called a Spitz nevus, both to the naked.
Spitz nevus Until the late 1940s, Spitz nevu swa c om ly di ag nos e ml Th eo rig nal t m dus by S. Spitz was juvenile melanoma A variety of other names have been proposed (spindled and epitheloid cell nevus) Spitz nevus came into use in the late 1960 Spitz S. Melanomas of childhood. Am J Pathol 1948, 24:591-609 Spiz nevus Mainly in caucasia (We actually talked to the dermatologist about the pathology report being a very typical spitz nevus after the plastic surgeon had called.) The plastic surgeon had taken and a wide amount of skin off her face, but apparently he hadn't gone as deep as the pathology indicated where there were still some cells Compound Spitz nevus from right calf of 24 year old male. 2A) Symmetrical, compound lesion associated with epidermal hyperplasia. 2B-C) Lesion is composed of fascicles and nests of epithelioid and spindle-shaped melanocytes with moderate amounts o
Junctional, compound or dermal nevus, composed of epithelioid melanocytes (large, with broad, pink cytoplasm, sometimes multinuclear). Compound Spitz nevi show often mitotic activity. Intraepidermal melanocytes are organized in nests and in single units and often epidermal scatter is present. Melanocytes are (at least focally) spindle-shaped. In contrast to ECH, desmoplastic Spitz nevus generally lacks an overlying hyperplastic epidermis and the epithelioid cells usually lie singly in a dense, eosinophilic, collagenous stroma . In addition, desmoplastic Spitz nevus shows diffuse immunoreactivity with S-100 
Desmoplastic Spitz Nevus Desmoplastic Spitz nevus is a rare subtype, more common in individuals in late adolescence or in adults than in chil-dren. Clinically, lesions present as papules with limited or pathology study, may resemble Spitz nevi. In general, these are usually amelanotic or pigmented lesions with differ-en Desmoplastic Spitz naevi present the pathologist with two problems. The lack of junctional proliferation may precipitate misdiagnosis as a non-melanocytic lesion such as an epithelioid dermatofibroma, cellular scar, benign mixed tumour or neurothekeoma The Spectrum of Spitz Nevi. Archives of Dermatology, 2005. Giuseppe Argenziano. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper. READ PAPER. The Spectrum of Spitz Nevi. Download. The Spectrum of Spitz Nevi 68. Hilliard NJ, Krahl D, Sellheyer K. p16 expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma. J Cutan Pathol. 2009;36(7):753-759. 69. George E, Polissar NL, Wick M. Immunohistochemical evaluation of p16INK4A, E-cadherin, and cyclin D1 expression in melanoma and Spitz tumors toni A and Antoni B patterns.35 Desmoplastic Spitz Controversy exists regarding the mechanism of des- nevus shows the general architecture of a benign mela- moplasia seen in DMs.7 One hypothesis suggests that nocytic neoplasm because it is symmetrical, well cir- tumor cells evoke a host response characterized by the cumscribed, and there is.
Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus. Am J Surg Pathol. 2004 Dec;28(12):1621-5. Previous case Next case Return to the Melanoma: general features slide se American Board of Dermatology & Pathology 1993 . American Board of Dermatology (Recertified 2010) 1992 . HONORS. Outstanding Faculty Member Wayne - State University 1996, 1999, 2005, 2011 Desmoplastic Spitz Nevus: A histopathological review and comparison with desmoplastic melanoma. Nojavan H, Cribier B, Mehregan D. Ann. Dermatologie. Pagetoid desmoplastic spitz, atypical sptiz or spitzoid melanoma, The nuclei appear uniform and there seems to be some maturation towards the base, therefore, favouring pagetoid/desmoplastic spitz or atypical spitz tumor over melanoma scar, desmoplastic nevus, desmoplastic Spitz nevus, sclerosing blue nevus, dermatofibroma, dermatofibrosar-coma protuberans, neural tumors, sarcomas, spindle cell squamous cell carcinoma, and atypical fibroxanthoma. Perhaps the most important initial step in distinguishing a DM is an examination of the dermal-epidermal junctio